Our Biomarkers

Your Baseline+ program is built around your blood. Our AHPRA-registered practitioners use a comprehensive panel of clinically selected markers to understand what is actually happening in your body, not just what looks normal on paper.

This is the full library of tests available through Baseline+. What is included in your program depends on which program you are on. Your practitioner may also recommend additional markers based on your intake and results.

Biological Age

High Sensitivity C-Reactive Protein (hs-CRP)
Chronic low-grade inflammation is one of the strongest predictors of accelerated biological ageing. Even mildly elevated hs-CRP sustained over time is associated with faster cellular decline and increased disease risk.
Elevated homocysteine damages DNA and blood vessels, and is strongly linked to cognitive decline and faster biological ageing.
One of the most reliable blood markers of biological age. DHEA-S peaks in your mid-20s and declines steadily. The rate of decline reflects adrenal reserve and overall vitality.
Chronically elevated cortisol accelerates cellular ageing, suppresses immune function, and disrupts hormonal balance across the board.
Sex hormone decline is both a cause and a marker of ageing. Tracking oestradiol over time gives your practitioner meaningful data about where you are in that process.
Declining testosterone is closely tied to biological ageing in both men and women, affecting muscle, cognition, mood, and metabolic function.
Chronically elevated blood sugar glycates cells, blood vessels, and organs. One of the most significant and most modifiable drivers of biological age.
Blood sugar control is one of the strongest predictors of how well your body ages. Even pre-diabetic glucose levels accelerate cellular decline.
Consistently low vitamin D is associated with accelerated immune ageing, higher rates of chronic disease, and increased mortality risk.
Both deficiency and excess ferritin are linked to oxidative stress, which drives cellular ageing. Finding and maintaining the right range matters more than most people realise.
A broad snapshot of how well your body key systems are holding up. Shifts in your FBC over time are often early indicators of systemic decline.
A useful long-term trend marker. Chronically elevated ESR reflects persistent inflammation, one of the key biological age accelerators.

Metabolic Health

Fasting Glucose
Your blood sugar level after not eating. One of the first markers to shift when metabolism starts to struggle, and often elevated for years before diabetes is diagnosed.
Reflects your average blood sugar over the past three months. Far more reliable than a single glucose reading for understanding how your body is managing sugar long-term.
Reveals how hard your pancreas is working to control blood sugar. Elevated fasting insulin is a strong early sign of insulin resistance, often appearing years before glucose rises.
Metabolic dysfunction shows up in fat levels early. Your practitioner reviews these alongside blood sugar markers to build the full picture.

Metabolic health and cardiovascular risk are closely linked. Elevated LDL in the context of insulin resistance signals a compounding risk worth addressing.

Low HDL is a consistent feature of poor metabolic health. It often drops alongside rising triglycerides when insulin resistance develops.

Chronic inflammation and metabolic dysfunction go hand in hand. Elevated hs-CRP often accompanies insulin resistance and poor metabolic health.
Rises in the context of metabolic stress. A functional marker of B vitamin metabolism that also reflects cardiovascular risk.
Elevated uric acid is closely linked to insulin resistance, metabolic syndrome, and gout risk. Often overlooked on standard panels.

Hormone Health

Testosterone (Total)
The primary sex hormone in both men and women. Affects energy, mood, libido, muscle mass, and fat distribution.

 Most testosterone in the blood is bound to proteins and unavailable to the body. This measures only the fraction your body can actually use.

A protein that binds to testosterone and oestradiol, making them biologically inactive. High SHBG can leave you with low usable hormones even when total levels look fine on paper.

The primary form of oestrogen. Important for bone health, mood, sleep, cardiovascular function, and reproductive health in both men and women.

Works alongside oestrogen to regulate the menstrual cycle. Low progesterone is common and often missed, contributing to cycle irregularities, poor sleep, and anxiety.

The signal your brain sends to trigger sex hormone production. Helps your practitioner understand whether a hormone imbalance is coming from the glands or the brain signalling.
Regulates reproductive function in both sexes. In women, rising FSH is one of the earliest signs of perimenopause.
An adrenal hormone that acts as a building block for sex hormones. Declines with age and is linked to energy, immunity, and hormonal balance.
Elevated prolactin in men and non-pregnant women can suppress sex hormones and affect libido, mood, and fertility.
The main signal your brain sends to your thyroid. The first marker to shift when thyroid function is off, even before other thyroid hormones move out of range.

The active form of thyroid hormone. Drives metabolism, energy, mood, and body temperature regulation at a cellular level.

The storage form of thyroid hormone, converted to T3 as needed. Helps your practitioner understand whether the thyroid is producing enough and converting efficiently.
Your primary stress hormone. Chronically elevated or depleted cortisol disrupts sleep, metabolism, immune function, and every other hormone in the system. Must be collected before 10am.
The most reliable marker of ovarian reserve. Gives women a clear picture of their reproductive window, independent of where they are in their cycle.

Heart Health

Cholesterol (Total)

 A snapshot of all cholesterol in your blood. On its own it does not tell the full story, but it is a useful starting point for understanding cardiovascular risk.

Often called the bad cholesterol. High levels contribute to plaque building up in artery walls over time, raising the risk of heart attack and stroke.
The protective kind. HDL helps clear other cholesterol out of the bloodstream. Higher levels are generally a good sign for heart health.
Fats circulating in your blood. Persistently high levels are linked to heart disease, poor metabolic health, and insulin resistance.
The main protein in HDL, the protective cholesterol. Higher ApoA1 reflects a stronger cardiovascular defence system.
Found in every harmful cholesterol particle. This test counts the actual particles carrying bad cholesterol, not just how much cholesterol is there. You can have normal cholesterol but too many harmful particles. ApoB catches that.

Detects low-level inflammation in the body. Chronic inflammation quietly damages blood vessels over time and raises heart disease risk, even in people with normal cholesterol.

An amino acid that rises when B vitamin metabolism is impaired. Elevated levels damage blood vessel walls and increase cardiovascular risk independently of cholesterol.
A clotting protein that also acts as an inflammation marker. High fibrinogen thickens the blood and is linked to increased cardiovascular and clotting risk.
A broad check on your blood cells. Anaemia and other blood conditions place extra load on the heart and can go undetected without this test.

Autoimmune

ANA (Antinuclear Antibody)
A broad screening marker for autoimmune activity. A positive result does not confirm a diagnosis but signals that your immune system may be reacting to your own tissue.
More specific than ANA. Elevated levels are strongly associated with lupus and other systemic autoimmune conditions.
A marker commonly associated with rheumatoid arthritis. Can also be elevated in other autoimmune and inflammatory conditions.
More specific than rheumatoid factor for rheumatoid arthritis, and can appear in the blood years before symptoms develop.
A broad marker of inflammation in the body. Rises during active autoimmune flares, infection, or other inflammatory states.
A sensitive inflammation marker. Elevated in active autoimmune and inflammatory conditions and useful for tracking disease activity over time.
One of your main antibody classes. Abnormal levels can point to immune deficiency, autoimmune activity, or conditions affecting immune cell production.
An antibody important for gut and respiratory immune defence. Abnormal levels are associated with autoimmune conditions and immune deficiency.
The first antibody your immune system produces in response to infection. Elevated levels can indicate active immune response or autoimmune activity.
The primary marker for autoimmune thyroid disease. Elevated TPO antibodies are the main driver of Hashimoto thyroiditis, the most common cause of thyroid dysfunction.
Used alongside TPO antibodies to complete the autoimmune thyroid picture. Elevated in Hashimoto and Graves disease.

Blood and Bone Marrow Function

Full Blood Count (FBC)
The foundation of any blood assessment. Measures red cells, white cells, and platelets to give a complete picture of how your blood is performing.
The protein in red blood cells that carries oxygen around the body. Low levels confirm anaemia. The FBC helps determine why.
Measures the average size of red blood cells. Abnormal size points your practitioner toward the likely cause of anaemia, whether that is iron, B12, folate, or something else.

 The average amount of haemoglobin in each red blood cell. Used alongside MCV to identify what type of anaemia is present.

The amount of iron currently circulating in your blood. A snapshot that needs to be interpreted alongside ferritin and transferrin for the full picture.
The protein that stores iron in your body. Low ferritin is one of the most common and most frequently missed causes of persistent fatigue, hair loss, and poor concentration.
The protein that transports iron through the blood. Helps your practitioner understand how efficiently your body is moving iron to where it needs to go.

 Measures how much iron your blood could carry. Elevated TIBC alongside low ferritin is a classic pattern of iron deficiency.

The percentage of your iron transport protein currently carrying iron. Low saturation confirms iron deficiency; very high saturation can suggest iron overload.
Essential for red blood cell production and nerve function. Deficiency develops slowly and can cause significant neurological symptoms before it shows clearly on basic tests.
Works alongside B12 to produce healthy red blood cells. Deficiency leads to a specific type of anaemia and is particularly important for people with MTHFR gene variants.
A broad marker of inflammation or disease activity. Elevated in chronic illness, autoimmune disease, and some bone marrow conditions.

A clotting protein that shows how efficiently your blood coagulates. Relevant for identifying bleeding risk or clotting disorders.

Genetic Insights

MTHFR Gene Variants (C677T, A1298C)
Affects how your body processes folate and performs methylation, a process central to DNA repair, detoxification, and neurotransmitter production. Certain variants are linked to elevated homocysteine, mood changes, and cardiovascular risk.
A functional blood marker closely tied to MTHFR and methylation status. Elevated levels damage blood vessels and are associated with cardiovascular disease, cognitive decline, and B vitamin insufficiency.
Influences how your body metabolises cholesterol and fat. Certain ApoE variants are associated with higher cardiovascular risk and have been widely studied in relation to cognitive health and longevity.

Body Composition Insights

Testosterone (Total)
A primary driver of lean muscle mass and fat distribution in both men and women. Low testosterone makes it significantly harder to build or maintain a healthy body composition.
The usable portion of testosterone. Total levels can look normal while free testosterone is too low to have any real effect on muscle, fat, or energy.
Binds to testosterone and reduces how much is available to your cells. High SHBG is a common reason why hormone levels look fine on paper but symptoms persist.
Chronically elevated cortisol promotes fat storage, particularly around the abdomen, and accelerates muscle breakdown. One of the most underestimated drivers of stubborn body composition issues.
Insulin resistance is one of the biggest drivers of fat accumulation, particularly visceral fat. This marker can reveal resistance long before blood sugar itself becomes a problem.
Long-term blood sugar dysregulation shapes body composition, promoting fat storage, muscle loss, and persistent energy crashes.
A three-month average of blood sugar levels. Sustained elevation accelerates fat storage and muscle breakdown over time.
Thyroid function governs your metabolic rate. Even subtle dysfunction can make weight management feel impossible despite genuine effort.
The active thyroid hormone driving metabolism at a cellular level. Low Free T3 often explains why someone feels sluggish and struggles with body composition despite doing everything right.
The storage form of thyroid hormone. Helps your practitioner understand whether conversion to the active form is happening efficiently.
Plays a role in muscle function, anabolic signalling, and fat metabolism. Deficiency is very common in Australia and often contributes to poor training response.
Declining DHEA-S is linked to reduced muscle mass, increased fat storage, and lower energy, particularly as people age.

Bone Health

Vitamin D (25-OH)
The most important nutrient for calcium absorption and bone mineralisation. Deficiency is widespread and significantly increases fracture risk and bone loss over time.
The primary structural mineral in bone. Blood levels are tightly regulated, so abnormal results signal an underlying issue with absorption, parathyroid function, or bone metabolism.
Works with calcium in bone formation and energy production. Imbalances can reflect kidney issues, vitamin D problems, or metabolic bone disease.
Essential for activating vitamin D and regulating calcium. Without adequate magnesium, even good calcium intake will not be used properly by the body.
Oestrogen is one of the most powerful protectors of bone density. Declining levels in perimenopause and menopause directly accelerate bone loss.

Important for bone maintenance in both men and women. Low levels are linked to reduced bone density and increased fracture risk.

Rising FSH is one of the earliest signs of the menopausal transition, and the accelerated bone loss that comes with it.

Gut Health

High Sensitivity C-Reactive Protein (hs-CRP)
A sensitive marker of systemic inflammation. Chronically elevated hs-CRP is often connected to gut wall inflammation and disrupted microbiome balance.
Anaemia is a common consequence of poor gut absorption. The FBC helps identify nutritional deficiencies that frequently stem from impaired gut function.
Iron deficiency is one of the most common signs that the gut is not absorbing nutrients efficiently. A full iron panel gives your practitioner the context to investigate further.
B12 absorption depends on the gut. Deficiency is a key indicator that gut function, particularly in the stomach and small intestine, may be compromised.

Like B12, folate depends on gut absorption. Low folate alongside low B12 points to a broader absorption issue worth investigating.

Rises when B12 and folate are insufficient for normal metabolism. A useful functional marker for identifying gut-driven nutrient deficiencies even when serum levels look borderline.
An important immune marker for the gut. Low total IgA can cause false negatives on other gut-related antibody tests and points to immune function issues in the digestive tract.

Heavy Metals

Lead

Accumulates in bone and soft tissue over years of exposure. Even low-level lead burden is associated with neurological effects, high blood pressure, and kidney damage.

The most common source is regular consumption of larger fish. Mercury accumulates in the nervous system and can affect mood, memory, and immune function over time.

Found in groundwater, rice, and some seafood. Chronic low-level exposure is linked to cardiovascular disease, skin changes, and increased cancer risk.

Found in cigarette smoke and some foods. Accumulates in the kidneys and causes progressive damage that develops silently over years of exposure.
Essential in small amounts but harmful in excess. High copper competes with zinc, disrupts neurological function, and can contribute to hormonal imbalance.
Often depleted alongside copper excess. Essential for immune function, wound healing, hormone production, and skin health.

Nutrition

Vitamin D (25-OH)

The most commonly deficient vitamin in Australia. Affects immune function, mood, bone health, muscle performance, and hormonal balance. Most people have no idea their levels are low.

Essential for nerve function, red blood cell production, and energy metabolism. Deficiency develops slowly and can cause significant neurological and cognitive symptoms before it shows on basic testing.

Critical for DNA repair, mood regulation, and cardiovascular health. Particularly important for people with MTHFR gene variants, who may have a reduced ability to use standard folate.

Your iron storage marker. Low ferritin is one of the most common and most frequently missed causes of fatigue, brain fog, and hair loss.
The amount of iron currently circulating. Assessed alongside ferritin and transferrin to give a complete picture of iron status.
One of the most common deficiencies and one of the least tested. Affects sleep quality, muscle recovery, stress response, and over 300 enzyme processes in the body.
Deficiency is far more common than standard testing reveals. Affects immunity, skin, hormonal function, and wound healing.
Needs to be assessed alongside zinc. The ratio between the two matters as much as the individual levels, and imbalance is often the root of unexplained symptoms.

Critical for thyroid hormone conversion and antioxidant defence. Australian soils are selenium-poor, making deficiency more common here than in many other countries.

A functional marker of B vitamin adequacy. Elevated levels can flag a deficiency even when B12 and folate appear within range on standard testing.
Converts carbohydrates into usable energy. Deficiency causes fatigue, muscle weakness, and nerve problems, and in severe cases can affect heart function.

Electrolytes

Sodium
The body primary fluid-balancing electrolyte. Low or high sodium affects blood pressure, hydration, nerve transmission, and cognitive clarity.
Critical for heart rhythm and muscle function. Even mild deficiency can cause cramps, fatigue, and heart palpitations.
Essential for muscle contraction, nerve signalling, and heart function. Abnormal levels are clinically significant and need to be investigated.

One of the most common deficiencies. Affects sleep quality, muscle recovery, stress response, and heart rhythm, yet rarely included in standard blood panels.

Works with calcium in energy production and bone metabolism. Imbalances can reflect kidney dysfunction or issues with vitamin D and parathyroid regulation.

Everything you need to know

Does my program include all of these tests?
No. This page shows the full library of tests available through Baseline+. What is included in your program depends on which program you purchased. Each program comes with a pre-set panel of markers selected for that health area, drawn from across these categories. Your practitioner may also recommend additional markers based on your intake and your individual situation.
Yes. Once you have an account you can access the patient portal and build your own testing bundle from the available tests. You do not need to purchase a program first. Keep in mind that tests purchased through a program are priced better than individual selections, so if your goals align with one of our programs, that is usually the better starting point.
Most standard blood tests only check a handful of things. The panels here go much further, looking at hormones, blood sugar, inflammation, nutrients, and more. A lot of what people have been told looks fine actually shows up when you test the right things.
Standard tests don’t always check the markers that matter most for how you’re actually feeling. And results are usually compared against a broad population average, not your individual picture. Your practitioner looks at your results alongside your symptoms and health history, not just the numbers on their own.
Not necessarily. Reference ranges are based on population averages, and being slightly outside one does not automatically mean something is wrong. Your practitioner looks at everything together, not just a single number in isolation.
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